Publications

2015年

原著論文

  1. Yoshinobu Kariya, Yukiko Kariya, Toshie Saito, Shuhei Nishiyama, Takashi Honda, Keiko Tanaka, Mari Yoshida, Kazuo Fujihara, Yasuhiro Hashimoto: Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica.  June 3: BBA Clinical, 126-134, 2015

 

2014年

原著論文

  1. Yoshinobu Kariya, Mayumi Kanno, Kana Matsumoto-Morita, Midori Konno, Yoshiki Yamaguchi, Yasuhiro Hashimoto: Osteopontin O-glycosylation contributes to its phosphorylation and cell adhesion properties. Biochem. J., 463(1):93-102,2014
  2. Masamichi Nagae, Kana Morita-Matsumoto, Seisuke Arai, Ikuo Wada, Yuka Matsumoto, Kiyoshi Saito, Yasuhiro Hashimoto and Yoshiki Yamaguchi:  Structural change of N-glycan exposes hydrophobic surface of human transferrin.  Glycobiology, Aug;24(8):693-702, 2014
  3. Yuka Matsumoto, Toshie Saito, Kyoka Hoshi, Hiromi Ito, Yoshinobu Kariya, Masamichi Nagae, Yoshiki Yamaguchi, Yoshiaki Hagiwara, Noriaki Kinoshita, Ikuo Wada, Kiyoshi Saito, Takashi Honda and Yasuhiro Hashimoto: In situ visualization of a glycoform of transferrin: Localization of α2,6-sialylated transferrin in the liver. J. Biochem., 2014 (in press) 

 

著書・総説など

 

  1. Kyoka Hoshi, Yuka Matsumoto, Toshie Saito, Hiromi Ito, Yoshinobu Kariya, Yoshiki Yamaguchi, Katsutoshi Furukawa, Hiroyuki Arai, Masakazu Miyajima, Hajime Arai, Hisashi Narimatsu, Kiyoshi Saito, Takashi Honda and Yasuhiro Hashimoto: A Glycan Marker for Idiopathic Normal Pressure Hydrocephalus  Glycoscience: Biology and Medicine  2014
  2. 星京香、橋本康弘  糖鎖バイオマーカーの新しいハイスループット測定法  医学のあゆみ  249/ 8, 676-681  2014/05

2013年

原著論文

  1. Kyoka Hoshi, Yoshinobu Kariya, Kiyomitsu Nara, Hiromi Ito, Kana Matsumoto, Masamicihi Nagae, Yoshiki Yamaguchi, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Atsushi Kuno, Hisashi Narimatsu, Keiro Shirotani, and Yasuhiro Hashimoto: Lectin-dependent inibition of antigen-antibody reaction: Application for measuring alpha2,6-sialylated glycoforms of transferrin. J. Biochem., 154(3): 229-232, 2013 

英文総説

  1. Yoshinobu Kariya,Yukiko Kariyaand Jianguo Gu: Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by N-glycosylation. Laminins: Structure, Biological Activity and Role in Disease. Nova Science Publishers, Inc. 29-51, 2013 

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著書・総説など

 

  1. 松本由香、齋藤 清、本多たかし、中島 円、宮嶋雅一、新井 一、橋本康弘  iNPHマーカーとしての髄液トランスフェリン  iNPH Now  10  2013       

 

2012年

原著論文

  1. S. Futakawa, K. Nara, M. Miyajima, A. Kuno, H. Ito, H. Kaji, K. Shirotani, T. Honda, Y. Tohyama, K. Hoshi, Y. Hanzawa, S. Kitazume, R. Imamaki, K. Furukawa, K. Tasaki, H. Arai, T. Yuasa, M. Abe, H. Arai, H. Narimatsu and Y. Hashimoto, “A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH”, Neurobiology of Aging, 33(8):1807-1815, 2012
  2. K. Miyazaki, K. Sakuma, Y. I. Kawamura, M. Izawa, K. Ohmori, M. Mitsuki, T. Yamaji, Y. Hashimoto, A. Suzuki, Y. Saito, T. Dohi, R. Kannagi: Colonic epithelial cells express specific ligands for mucosal macrophage immunosuppressive receptors siglec-7 and -9.  J. Immunology, 188(9):4690-700, 2012
  3. N. Kakuda, M. Shoji, H. Arai, K. Furukawa, T. Ikeuchi, K. Akazawa, M. Takami. H. Hatsuta, S. Murayama, Y. Hashimoto, M. Miyajima, H. Arai, Y. Nagashima, H. Yamaguchi, R.Kumano, K. Nagaike: Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease.  EMBO Molecular Mediciene,  4/ 4: 344-52, 2012

著書・総説など

  1. 橋本康弘*、菊池一郎、宮嶋雅一、新井一、古川勝敏、荒井啓行、松本由香*、齋藤清*、城谷圭朗*  認知症の髄液糖鎖マーカー  Cognition and Dementia  11/ 2, 35-40  2012 

2011年

原著論文

  1. Keiro Shirotani, Satoshi Futakawa, Kiyomitsu Nara, Kyoka Hoshi, Toshie Saito, Yuriko Tohyama, Shinobu Kitazume, Tatsuhiko Yuasa, Masakazu Miyajima, Hajime Arai, Atsushi Kuno, Hisashi Narimatsu and Yasuhiro Hashimoto, “High Throughput ELISAs to Measure an Unique Glycan on Transferrin in Cerebrospinal fluid: A Possible Extension Toward Alzheimer’s Disease Biomarker Development”, International Journal of Alzheimer's Disease, 352787  2011/08
  2. M. Nakajima, M. Miyajima, I. Ogino, M. Watanabe, H. Miyata, K. L. Karagiozov, H. Arai, Y. Hagiwara, T. Segawa, K. Kobayashi and Y. Hashimoto, “Leucine-rich α-2-glycoprotein is a marker for idiopathic normal pressure hydrocephalus”, Acta Neurochirurgica, 153(6):1339-46, 2011
  3. Yuko Akasako, Kiyomitsu Nara, Yoshitaka Nagai, Yasuhiro Hashimoto, “Inhibition of ganglioside synthesis reduces the neuronal suvival activity of astrocytes”, Neuroscience Letters, 488(2):199-203, 2011

著書・総説など

  1. Toshiyuki Yamaji, Yoshiki Yamaguchi, Motoaki Mitsuki, Shou Takashima, Satoshi Waguri, Yasuhiro Hashimoto and Kiyomitsu Nara, “3D modeling of a natural killer receptor, Siglec-7: critical amino acids for glycan-binding and cell death-inducing activity”, 「Modeling and Simulation in Engineering」, INTECH, 2011 (ISBN: 978-953-307-959-2) in press
  2. 二川了次、奈良清光、城谷圭朗、本多たかし、橋本康弘:“認知症の髄液学-診断マーカーとしての糖鎖修飾-”、認知症関連分子生物学各論「日本臨床」、69(8), 69-73, 2011
  3. 二川了次、橋本康弘:“認知症の糖鎖マーカー:特発性正常圧水頭症を例として”、「脳21」、金芳堂、京都 Vol.14 No.1 p.32-36, 2011
  4. Toshiyuki Yamaji and Yasuhiro Hashimoto, “Recombinant sugar binding proteins and their functional analysis, Siglec-7”, Japan Consortium for Glycobiology and Glycotechnology DataBase, analysis and detection, l2010年

2010年

原著論文

  1. S. Kitazume, Y. Tachida, M. Kato, Y. Yamaguchi, T. Honda, Y. Hashimoto, Y. Wada, T. Saito, N. Iwata, T. Saido and N. Taniguchi, “Brain endothelial cells produce amyloid-beta from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form”, J. Biol. Chem., 285(51):40097-103, 2010
  2. S. Kitazume, R. Imamaki, K. Ogawa, Y. Komi, S. Futakawa, S. Kojima, Y. Hashimoto, J. D. Marth, J. C. Paulson and N. Tanigchi, “<alpha>2,6-Sialic acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling”, J. Biol. Chem., 285(9):6515-21, 2010

著書・総説など

  1. 橋本康弘、二川了次、宮嶋雅一、北爪しのぶ、奈良清光、城谷圭朗、久野敦、伊藤浩美、本多たかし、古川勝敏、田﨑和洋、荒井啓行、湯浅龍彦、阿部正文、成松久、新井一:“病因・病態解明に向けて(B)髄液バイオマーカー”、特発性正常圧水頭症(iNPH);病態研究最近の進歩、「臨床神経学」、日本神経学会事務局、東京、50, 971-972, 2010
  2. 橋本康弘、北爪しのぶ:“アルツハイマー病の原因酵素が糖鎖を変えていた”、 「糖鎖を知る-その素顔と病気への挑戦」、谷口直之、鈴木明身、西澤敏雄監修、(独)科学技術振興機構、p.122-128, 2010

2009年

原著論文

  1. Shinobu Kitazume, Kazuko Ogawa, Satoshi Futakawa, Yoshiaki Hagiwara, Hajime Takikawa, Michio Kato, Akinori Kasahara, Eiji Miyoshi, Naoyuki Taniguchi, Yasuhiro Hashimoto, “Molecular insights into b-galactoside <alpha>2,6-sialyltransferase secretion in vivo”, Glycobiology, 2009,19(5):479-487
  2. Satoshi Futakawa; Shinobu Kitazume; Ritsuko Oka; Kazuko Ogawa; Yoshiaki, Hagiwara; Akinori Kinoshita, and Kazuya Miyashita, and Yasuhiro Hashimoto "Development of sandwich enzyme-linked immunosorbent assay systems for plasma b-galactoside <alpha>2,6-sialyltransferase, a possible hepatic disease biomarker", Analytica Chimica Acta, 2009, 631,116-120

2008年

原著論文

  1. Yuriko Tachida, Kazuhiro Nakagawa, Takashi Saito, Takaomi C. Saido, Gaku Sakaguchi, Akira Kato, Shinobu Kitazume, and Yasuhiro Hashimoto. “Interleukin-1beta upregulates TACE to enhance alpha-cleavage of APP in neurons: Resulting decrease of Abeta producton. J. Neurochem, 2008, 104(5):1387-1393

著書・総説など

  1. Shinobu Kitazume, Shou Takashima and Yasuhiro Hashimoto, “Processing of glycosyltransferases by Alzheimer’s bsecretase(BACE1)”, in Experimental Glycoscience, eds. N. Taniguchi et al., 192-194, 2008
  2. 北爪しのぶ、橋本康弘:“糖転移酵素の修飾機構と意義”、「蛋白質核酸酵素」 増刊号 糖鎖情報の独自性と普遍性、9月号増刊、53(12), 1456-1459,2008

2007年

原著論文

  1. Ichiro Sugimoto, Satoshi Futakawa, Ritsuko Oka, Kazuko Ogawa, Jamey D. Marth, Eiji Miyoshi, Naoyuki Taniguchi, Yasuhiro Hashimoto amd Shinobu Kitazune. “Beta-Galactoside alpha 2,6-sialyltransferase I Cleavage by BACE1 Enhances the sialylation of soluble glycoproteins -a Novel Regulatory mechanism for alpha 2,6-sialylation,”  J. Biol. Chem, 2007 282: 34896 - 34903
  2. Naoko Nagai, Hiroko Habuchi , Shinobu Kitazume , Hidenao Toyoda , Yasuhiro Hashimoto and Koji Kimata. “Regulation of heparan sulfate 6-O- sulfation by b-secretase activity”,  J. Biol. Chem, 2007, 282: 14942-14951

2006年

原著論文

  1. S. Kitazume, R. Oka, Y. Tachida, K. Ogawa, K. Nakagawa, S. Takashima, Y. Hashimoto: Screening a series of sialyltransferases as possible BACE1 substrates.  Glycoconjugate J., 282: 14942 – 14951, 2007C. Hattori, M. Asai, H. Onishi, N. Sasagawa, Y. Hashimoto, T. Saido, K. Maruyama and S. Ishiura, “BACE1 interacts with lipid raft proteins,” J. Neurosci. Res., 84, 912-917,2006
  2. H. Sakuraba, Y. Chiba, M. Kotani, I. Kawashima, M. Ohsawa, Y. Tajima, Y. Takaoka, Y. Jigami, H. Takahashi, Y. Hirai, T. Shimada, Y. Hashimoto, K. Ishii, T. Kobayashi, K. Watabe, T. Fukushige, and T. Kanzaki, “Corrective effect of recombinant human alpha-galactosidase having N-linked sugar chains suitable for lysosomal delivery on Fabry mice,” J. Hum. Genet., 51, 341-352, 2006
  3. M. Asai, C. Hattori, N. Sasagawa, T. Kobayashi, K. Maruyama, Y. Kiso, S. Ishiura, Y. Hashimoto, T.C. Saido: A novel beta-secretase inhibitor KMI-429 reduces amyloid beta-peptide (Abeta) production in amyloid precursor protein (APP) transgenic and wild-type mice.  J. Neurochem., 96, 533-540, 2006
  4. K. Nakagawa, S. Kitazume, R. Oka, K. Maruyama, T.C. Saido, Y. Sato, T. Endo, Y. Hashimoto: Sialylation enhances the secretion of neurotoxic amyloid-beta peptides.  J. Neurochem., 96, 924-933, 2006

著書・総説など

  1. 北爪しのぶ、中川和博、山本正雅、樋口真人、西道隆臣、橋本康弘、“アルツハイマー病βセクレターゼによるシアル酸転移酵素切断のpathophysiology,”日本血清止血学会誌,17, 78-82, 2006

2005年

【原著論文】

  1. S. Kitazume, R. Oka, Y. Tachida, K. Ogawa, K. Nakagawa, Y. Luo, M. Citron, H. Shitara, C. Taya, H. Yonekawa, J.C. Paulson, E. Miyoshi, N. Taniguchi, Y. Hashimoto: In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer’s beta-secretase (BACE1).  J. Biol. Chem., 280, 8589-8595, 2005
  2. T. Yamaji, M. Mitsuki, T. Teranishi, Y. Hashimoto: Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: Attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs. Glycobiology, 15, 667-676, 2005
  3. N. Kotani, S. Kitazume,K. Kamimura,S. Takeo, T. Aigaki, H. Nakato,Y. Hashimoto: Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase. J. Biochem., 137, 315-322, 2005

【著書・総説など】

  1. 山地俊之,北爪しのぶ,中川和博,橋本康弘,“シグレック:抑制性シグナルを伝えるレクチン分子,”遺伝子医学MOOK3「糖鎖と病気」, 谷口直之編,(株)メディカルドゥ,130-137, 2005
  2. 北爪しのぶ:“アルツハイマー病と糖鎖”、「糖鎖科学の新展開」、谷口直之、伊藤幸成監修、(株)エヌ・ティー・エス、東京、p.201-205, 2005
  3. 山地俊之、三ツ木元章、橋本康弘:“Natural killer (NK)細胞の活性化レセプターと抑制性レセプター”、「糖鎖科学の新展開」、伊藤幸成、谷口直之監修、(株)エヌ・ティー・エス、東京、p.274-280, 2005
  4. 北爪しのぶ、橋本康弘:“アルツハイマー病βセクレターゼによる糖転移酵素のプロセシング”、「未来を拓く糖鎖科学」、永井克孝監修、金芳堂、京都、p.250-252, 2005
  5. 山地俊之,三ツ木元章,橋本康弘,“Natural killer (NK)細胞の活性化レセプターと抑制性レセプター,”糖鎖科学の新展開,伊藤幸成,谷口直之監修,(株)エヌ・ティー・エス,東京,p.274-280, 2005

2004年

【原著論文】

  1. K. Miyazaki, K. Ohmori, M. Izawa, T. Koike, K. Furukawa, T. Yamaji, Y. Hashimoto, A. Suzuki, R. Kannagi: Loss of disialyl Lewisa, the ligand for lymphocyte inhibitory receptor Siglec-7, associated with increased sialyl Lewisa expression on human colon cancers.  Cancer Res., 64, 4498-4505, 2004
  2. S. Kitazume, M. Suzuki, T.C. Saido, Y. Hashimoto:  Involvement of proteases in glycosyltransferase secretion: Alzheimer’s beta-secretase-dependent cleavage and a following processing by an aminopeptidase.  Glycoconjugate J., 21, 25-29, 2004
  3. I. Ichinose, Y. Hashimoto , T. Kunitake: Overall wrapping of bio-macromolecules (Dextran, Amylopectin, and Horse Hart Cytochrome c) with Ultrathin Silicate Layer.  Chem. Lett., 33, 656-657, 2004
  4. S. Kitazume, T.C. Saido, Y. Hashimoto: Alzheimer’s beta-secretase cleaves a glycosyltransferase as a physiological substrate.  Glycoconjugate J., 20, 59-62, 2004

【著書・総説など】

  1. 北爪しのぶ、小谷典弘、中藤博志、西道隆臣、橋本康弘:アルツハイマー病βセクレターゼの基質としての糖転移酵素.蛋白質核酸酵素,49, 2468-2472, 2004

2003年

【原著論文】

  1. S. Kitazume, Y. Tachida, R. Oka, N. Kotani, K. Ogawa, M. Suzuki, N. Dohmae, K. Takio, T.C. Saido, Y. Hashimoto:  Characterization of alpha2,6sialyltransferase cleavage by Alzheimer’s beta-secretase (BACE1).  J. Biol. Chem., 278, 14865-14871, 2003
  2. N. Chen, A. Furuya , Y. Shinoda, M. Yumoto, A. Ohtake, K. Sato, Doi H, Y. Hashimoto, Y. Kudo, H. Higashi: Extracellular carbohydrate-signal triggering cAMP-dependent protein kinase-dependent neuronal actin-reorganization.  Neuroscience, 122: 985-995, 2003
  3. N. Chen, S. Furuya, H. Doi, Y. Hashimoto, Y. Kudo, H. Higashi: Ganglioside/Calmodulin kinase II signal inducing cdc42-mediated neuronal actin-reorganization.  Neuroscience, 120, 163-176, 2003

【著書・総説など】

  1. T. Yamaji, K. Nakamura, S. Amari, A. Suzuki, Y. Hashimoto: Characterization of sugar-binding specificity of Siglec family proteins.  in Methods in Enzymol, "Carbohydrate recognition in biological systems", edited by Y.C. Lee and R. Lee, 363, 104-113, 2003
  2. 北爪しのぶ,西道隆臣,橋本康弘:βセクレターゼによるシアル酸転移酵素の切断:切断に連鎖しておこるアミノペプチダーゼによるプロセッシング.細胞工学「セクレターゼによる膜タンパク質切断の生物学」,22, 636-639, 2003
  3. 北爪しのぶ,西道隆臣,橋本康弘:BACE1 と糖転移酵素.蛋白質核酸酵素 増刊号「糖鎖機能:第3の生命鎖」, 48, 984-989, 2003
  4. 山地俊之,橋本康弘:シアル酸認識分子とその機能.蛋白質核酸酵素 増刊号「糖鎖機能:第3の生命鎖」, 48, 1098-1105, 2003

2002年

【原著論文】

  1. H. Takahashi, Y. Hirai, M. Migita, Y. Seino, Y. Fukuda, H. Sakuraba, R. Kase, T. Kobayashi, Y. Hashimoto, T. Shimada: Long-term systemic therapy of Fabry Disease in a knockout mouse by adeno-assciated virus-mediated muscle-directed gene transfer.  Proc. Natl. Acad. Sci. USA, 99, 13777-13782, 2002
  2. T. Yamaji, T. Teranishi, M.S. Alphey, P.R. Crocker, Y. Hashimoto:  A small region of the natural killer cell receptor, Siglec-7, is responsible for the unique specificity for a2,8-disialyl and branched a2,6-sialyl residues: a comparison with Siglec-9.  J. Biol. Chem., 277, 6324-6332, 2002
  3. K. Nakamura, T. Yamaji, P.R. Crocker, A. Suzuki, Y. Hashimoto:  Lymph node macrophages, but not spleen macrophages, express high levels of unmasked sialoadhesin: Implication for the adhesive properties of macrophages in vivo.  Glycobiology, 12, 1-8, 2002

【著書・総説など】

  1. Y. Hashimoto and C.B. Hirschberg: Heparan sulfate N-sulfotrasferase-1 (NST-1). in “Handbook of Glycosyltransferases and Their Related Genes,” edited by Taniguchi N., Honke K. and Fukuda M., pp.484-490, Springer-Verlag, Tokyo, 2002
  2. 北爪しのぶ,西道隆臣,橋本康弘:糖転移酵素とプロテアーゼ.「ポストゲノム時代の糖鎖生物学がわかる」谷口直之編,羊土社,98-102, 2002
  3. 北爪しのぶ,西道隆臣,橋本康弘:アルツハイマー病に関わるβセクレターゼと糖鎖,バイオサイエンスとインダストリー.60, 685-686, 2002
  4. 北爪しのぶ,西道隆臣,橋本康弘:アルツハイマー病βセクレターゼの新しい基質の発見:βセクレターゼによる糖転移酵素の切断とその意義.生化学,74, 1180-1183, 2002
  5. 橋本康弘:30項目執筆.看護学大事典,内薗耕二、小坂樹徳監修,メヂカルフレンド社,2002